Methylation patterns are often markedly different in cancer cells compared with normal cells. Methylation is a natural process that chemically modifies DNA to regulate gene expression in cells. "This study evaluated the performance of several next-generation DNA sequencing methods."īased on study results, the research team selected a methylation-based DNA sequencing method for further study. "DNA from dying cells spills into the circulation, providing an opportunity to detect cancer-related material in the peripheral bloodstream," Dr. The samples from participants with cancer represented more than 50 cancer types, including breast, colorectal, esophageal, gallbladder, bladder, gastric, ovarian, head and neck, pancreatic and lung cancers, and lymphoid leukemia and multiple myeloma. They enrolled more than 1,200 of the total 6,689 participants in the multi-institutional trial, called Circulating Cell-free Genome Atlas (CCGA) Study.Ĭlinical information and tissue and blood specimens were collected from 2,482 study participants diagnosed with cancer and 4,207 without a diagnosis of cancer. Roberts, M.B., Ch.B., Ph.D., and Dennis Wigle, M.D., Ph.D., in Minnesota, to develop a test to reliably detect cancer signals in the blood. Bryce, M.D., at Mayo Clinic in Arizona David D. This is expected to lead to improved survival."ĭr. "Development of a single blood test for multicancer detection should facilitate cancer diagnoses at earlier stages, before the onset of symptoms. Liu, M.D., a medical oncologist at Mayo Clinic in Rochester, Minnesota, and lead author of the published study. "There are individuals who do not or cannot comply with existing screening recommendations, and there are many cancers for which we currently do not have a validated screening approach," said Minetta C.
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